This month we turn our attention to the colloid debate. As most of you are aware, there has been a huge paradigm shift in the use of synthetic colloids in human medicine that has "bled" over (no pun intended) to the veterinary emergency and critical care arena.
For your reading pleasure, we have selected the following for your review. We really appreciate your comments and hope you will visit our blog!!
From the Jan/Feb issue of JVECC there are two salient (and open access) articles (this particular issue is free!)
State of the Art Reviews
The crystalloid‐colloid debate: Consequences of resuscitation fluid selection in veterinary critical care. Dava Cazzolli, Jennifer Prittie
Excellent review of the human and veterinary literature including prospective and restrospective studies, as well as experimental models. In human patients, colloids have failed to demonstrate outcome advantage. Clinical data indicates that hydroxyethyl starch solutions may be assoicated with significant adverse events. The ability to apply these findings to our species of interest is unknown however critical re-evaluation of veterinary resuscitation strategies is justified.
State of the Art Reviews
Controversies in the use of hydroxyethyl starch solutions in small animal emergency and critical care. Katja N. Adamik, Ivayla D. Yozova, Nadine Regenscheit
Both human and veterinary data synthesis is presented. No current veterinary consensusu recommendations on the use of hydroxyethyl starch exists. Veterinary studies are needed to achieve evidence to enable the formulation of the guidelines.
JVIM 2015; 29:276-285 Open Access
"Effects of Synthetic Colloid Administration on Coagulation in Healthy Dogs and Dogs with Systemic Inflammation."
V Gauthier, M.K. Holowaychuk, C.L. Kerr, A.M.E. Bersanas, R. Darren Wood
Bolus administration to dogs with systemic inflammation resulted in a transient hypocoagulation characterized by prolonged aPTT, decreased clot formation speed, decreased clot strength. and acquired Type 1 von Willebrand Disease.
Best Practices and Research. Clinical Anesthesiology 2014 Sept: 28 (3): 275-283 "Whats new in volume therapy in the Intensive Care Unit"
Synthetic Colloids are more effective than crystalloids in early shock resuscitation and surgery. However, these colloids may not be beneficial later in the course of intensive care treatment and are best avoided in patients with risk for Acute Kidney Injury 25208962
Annals of Intensive Care 2014; 4:38 "Resuscitation: Impact on Patient Outcomes"
There is no clear benefit associated with the use of colloids compared to crystalloids. Hydroxyethyl starch has been associated with increased incidence of acute kidney injury and the need for renal replacement therapy. 25612168